Evolutionary selection between alternative modes of gene regulation
نویسندگان
چکیده
منابع مشابه
Evolutionary selection between alternative modes of gene regulation.
Microorganisms employ a wealth of gene regulatory mechanisms to adjust their growth programs to variations in the environment. It was pointed out long ago [Savageau M (1977) Proc Natl Acad Sci USA 74: 5647-5651] that the particular mode of gene regulation employed may be correlated with the "demand" on the regulated gene, i.e., how frequently the gene product is needed in its natural habitat. A...
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Switching on a gene typically involves either a transcription factor that binds to stimulate transcription, or a repressor that releases to allow transcription. In both cases, the regulatory protein responds to an external biochemical signal. Control theory assigns the label ‘‘doublepositive’’ ( ), to the regulation mode in which the signal activates a factor that activates the gene, and ‘‘doub...
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The protein diversity that exists today has resulted from various evolutionary processes. It is well known that gene duplication (GD) along with the accumulation of mutations are responsible, among other factors, for an increase in the number of different proteins. The gene structure in eukaryotes requires the removal of non-coding sequences, introns, to produce mature mRNAs. This process, know...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0808500106